QUANTITATIVE VARIATIONS IN L CHAIN TYPES IN GUINEA PIG ANTIHAPTEN ANTIBODIES
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چکیده
منابع مشابه
Quantitative Variations in L Chain Types in Guinea Pig Antihapten Antibodies
In guinea pig purified antihapten antibodies, the proportion of molecules bearing the kappa- or lambda-type of L chains (K or L molecules) may diverge markedly from that found in normal gamma(2)-globulins. This has been evaluated by precipitation of I(131)-labeled antibody preparations using a specific anti-lambda-chain antiserum. Anti-DNP antibodies isolated 3 wk after immunization of guinea p...
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I t is well known that mammalian immunoglobulins x consist of two types of polypeptide chains, H and L (1, 2). In human ]mmunoglobulins, L chains were found to be of two distinct types (a and )~) which differ widely in their amino acid composition and in the peptides which can be detected by fingerprint analysis (3). Two types of molecules (K or I,) bearing either Kor ),-types of L chains, in a...
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Antibodies can be considered to be molecules with two distinct sets of properties: the capacity to react specifically with antigen, and the capacity to mediate a variety of biological reactions. Some of these are: anaphylaxis, which in the guinea pig may depend upon the ability of these molecules to react with unidentified tissue receptors (1) or cell lysis (2, 3) and opsonization (4, 5) which ...
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Two types of light polypeptide chain (kappa and lambda) are present in guinea pig immunoglobulins. The ratios of K/L molecules in anti-hapten antibodies differ sometimes markedly from that found in normal serum. Anti-DNP antibodies and anti-pipsyl antibodies have, respectively, a higher and a lower than normal K/L ratio. The possibility that the L chain type affects the range of configurations ...
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In the previous studies the relaxant, anti-cholinergic (functional antagonism) and anti-histaminic effects of Nigella sativa have been demonstrated on guinea pig tracheal chains. To elucidate the main substance responsible for the relaxant effect of this plant, the effect of thymoquinone, one of the main constituent of Nigella sativa was examined in this study. The bronchodilatory effects of th...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1966
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.124.5.805